Coronaviruses, however, are not expected to do this, said Bethany Moore, chair of the University of Michigans Department of Microbiology and Immunology. The CDC says that the COVID-19 vaccines do not change or interact with your DNA in any way, claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. 3401 Civic Center Blvd. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. N. Engl. The study tested whether the vaccines mRNA could be converted to DNA, and found that this was the case in certain lab-altered liver cell lines under experimental conditions. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. They used different concentrations of the vaccine and multiple timepoints to measure: Some pointed to this paper as proof that COVID-19 vaccines alter DNA. The Study Has Received A Lot of Media Attention, What Are Your Thoughts on That? The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. More information: MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. The research was conducted at Lund University. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more followers 129 videos. Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. By Meiling Lee. selenagomez. PCR was run on all samples with primers targeting BNT162b2, as shown in Figure 1 and Table 1. What are the next steps in this research? Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. The paper does not provide such evidence. official website and that any information you provide is encrypted The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Huh7 cells were treated without (Ctrl) or with 0.5 g/mL of BNT162b2 for 6, 24, and 48 h. Genomic DNA was purified and digested with 100 g/mL RNase. Additionally, the mRNA vaccine does in fact travel to the liver and other locations such as ovaries. 2022 Nov;28(11):2273-2287. doi: 10.1038/s41591-022-02061-1. Markus Aldn et al, Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, Current Issues in Molecular Biology (2022). Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis. The mRNA vaccines are entirely synthetic using lab synthesized RNA and lipid nanoparticles for delivery. A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. The site is secure. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. No information in this video should ever be considered as a substitute for advice from a healthcare professional.\r\rURL list from Friday, Feb. 25 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rFrontiers | Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines | Genetics\rhttps://www.frontiersin.org/articles/10.3389/fgene.2020.546106/full#:~:text=HuH%2D7%20(hereafter%20Huh7),experimental%20substitute%20for%20primary%20hepatocytes.\r\rURL list from Monday, Feb. 28 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rLINE-1 protein localization and functional dynamics during the cell cycle | eLife\rhttps://elifesciences.org/articles/30058\r\rTime evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA | bioRxiv\rhttps://www.biorxiv.org/content/10.1101/2021.08.20.457104v1\r\rReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues - PubMed\rhttps://pubmed.ncbi.nlm.nih.gov/33958444/\r\rNo evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues - PMC\rhttps://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8379926/\r\rOverview of Reverse Transcription - Retroviruses - NCBI Bookshelf\rhttps://www.ncbi.nlm.nih.gov/books/NBK19424/\r\rNuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus | Nature Microbiology\rhttps://www.nature.com/articles/s41564-020-0735-8\r\rChimeric RNA - Wikipedia\rhttps://en.wikipedia.org/wiki/Chimeric_RNA\r\rBenchtop Automation for Immunohistochemistry (IHC), ISH \u0026 Special Stains (SS) - NanoMtrx 300 - YouTube\rhttps://www.youtube.com/watch?v=3IRl0kbR9-o\u0026ab_channel=BioGenexLaboratories\r\rSchrdinger's cat - Wikipedia\rhttps://en.wikipedia.org/wiki/Schr%C3%B6dinger%27s_cat Childrens Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). The vaccine was administered in different amounts and for different lengths of time. In adifferent study, the spike proteins made in the body after receiving a Pfizer COVID-19 shot have been found on tiny membrane vesicles called exosomesthat mediate cell-to-cell communication by transferring genetic materials to other cellsfor at least four months after the second vaccine dose. Sudden deaths of Canadian No added sugar, full of protein and chocolate! Finally, as the authors pointed out, expression of LINE-1 has been shown to increase during viral infections, including with SARS-CoV-2 virus. Epub 2021 Nov 10. Epub 2022 Feb 3. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. 2022 Dec 9;14(12):e32361. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. Safety and Immunogenicity of Two RNA-Based COVID-19 Vaccine Candidates. The whole process occurred rapidly within six hours. Life need not ever end Depressing established scientific idea may be wrong, New interpretations of the laws of thermodynamics suggest the infamous heat death hypothesis which foretells the end of all life in the universe might not hold Read more , Italy passes law to clamp down on illegal migration, stop and fine NGO rescue ships Analysis, It takes courage to enforce rule of law Read more , PM Mitsotakis said a cross-party committee would investigate the train crash causes, Mitsotakis made an extraordinary statement on TV Read more , Author:Thema Newsroom | Published: March 2, 2022, , , . A gene that the researchers studied produces the protein LINE-1. Accessibility statement. Lund University Associate Professor Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith But that wasnt observed in this study. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. 2022 The Childrens Hospital of Philadelphia. In the cell line in a petri dish, you dont have those checks in place.. Getty badbunny. Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). Accessibility This is important for two reasons; both of which were acknowledged by the authors. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. Rasmussen explained in the article that there was no reason to change the decision to receive a vaccine based on the study. A new study from Lund University in Sweden on how the Pfizer-BioNTech COVID-19 vaccine affects human liver cells under experimental conditions, has been viewed more than 800,000 times in just over a week. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). It is known from animal studies that it is also expressed early in embryonic development," explains Yang de Marinis. A clip being shared online in recent days shows three doctors, who have spread misinformation about the vaccines in the past, discussing the Swedish study and falsely claiming it demonstrates that the Pfizer vaccine reverse transcribes and installs DNA into the human genome, leading to harmful effects. Illustration, BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. The pharmaceutical industry is dangerous to health. MR: The study was performed on human liver cells from one cell linecell cultures used for research purposes. They are not sure if it gets integrated in our DNA or not. But keep in mind, when the mRNA or adenovirus particles do hit cells outside of the liver or the site of injection, they're still causing them to express Spike protein anchored on their surfaces, not dumping it into the circulation. During the study, the researchers were able to detect DNA that had been converted from the vaccines mRNA in the lab-modified cell. doi: 10.1128/Spectrum.01162-21. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. Some viruses, like HIV, are known to be able to convert RNA to DNA and then incorporate that DNA into host cells genome, which is one thing that makes the illness difficult to treat. Montoya JG, Adams AE, Bonetti V, Deng S, Link NA, Pertsch S, Olson K, Li M, Dillon EC, Frosch DL. Spetzofai is a rustic spicy Greek dish that is made with thick sausages and long green and red peppers in a rich tomato sauce. :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rChapters00:00 introduction00:45 Link to the summary01:00 Review of the reference material02:19 Cell preparation for the vaccine03:35 Vaccine addition to the cells06:00 RT-PCR for find RNA and then DNA13:39 Imaging of the cells and the LINE-1 protein, ORF-1 protein, and the DNA18:27 Measuring the volume of proteins in the cytosol and the nucleus22:35 DNA purification and verification28:41 Results28:42 LNP enters the liver cells efficiently29:33 LINE-1 gene is expressed30:46 ORF-1 found in cytosol and the nucleus36:01 DNA from the vaccine found in the cell43:30 Questions not answeredDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. Pfizer did not comment on the studys findings, the Epoch Times reported, stating only that its mRNA vaccine does not alter the human genome. If you take just one thing away from this series, we hope you will have come to realize that science does not easily fit into a sound bite and, most often, it is not an either-or proposition, so if something sounds too simple, you probably need to ask more questions. Our monetization model empowers Citizen Journalists to report the news in local and national markets. Skip to main content. Why liver cells and why the specific dose? They used different concentrations of the vaccine and Side Effects. https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support). We show that the vaccine enters liver cells as Before Skyros in best 10 list of islands to escape everything and everyone: CNN Travel, Train collision in Larissa: It was bad timing The station master admitted the fatal mistake, SpaceX Doubles Number of Rocket Launches (infographic), Russians shot down six drones in Crimea, accusing Ukraine of targeting civilian infrastructure, President Sakellaropoulou visited site of train collision (photos), Train collision Pope Francis expresses condolences to the families of the victims, Greek Transport Minister Karamanlis resigns over train collision, Mayor Lori Lightfoot loses re-election in Chicago, Train collision Russian Foreign Ministry expresses deep condolences to families of victims, Train collision French President Macron tweets in Greek his support, Tom Sizemore end of life decision looms after doctors say no further hope following stroke, Bill Gates finally explains why hes buying so much US farmland, Train collision: The Greek flag is at half-mast at the Parliament & Ministry of Foreign Affairs, Mitsotakis: We will find out the causes, we will do everything in our power to prevent it from happening again, Russia has just one tank factory churning out 20 tanks a month, with demand outstripping production by a factor of ten, Politico: We have a real UFO problem & its not balloons, Train collision: Chilling videos shortly after the head-on collision (videos). In fact. Your browser has javascript turned off or blocked. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. Professor at Infection Medicine Dr. Peter McCullough, an internist, cardiologist, and epidemiologist,wrote on Twitterthat the Swedish studys findings have enormous implications of permanent chromosomal change and long-term constitutive spike synthesis driving the pathogenesis of a whole new genre of chronic disease.. MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? Click here:\rhttps://www.drbeen.com/yt-special-p/\r\rWant to support this work? Two people in their 60s who received the shot were diagnosed with Guillain-Barre syndrome, out of about 20,000 vaccine recipients who participated in Pfizers Phase 3 The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. This article was produced by the Reuters Fact Check team. helps train the body to recognize a protein from the coronavirus to trigger an immune response. The https:// ensures that you are connecting to the In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. J. Med. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. The results have been widely discussed across social media but the results have in many cases been misinterpreted. It is important to bear in mind that the liver cells in this study are more genetically unstable than our own liver cells. selenagomez. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis 41.1M. Your feedback is important to us. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. The mRNA is converted to DNA as early as six hours after exposure to the vaccine. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. These tools for evaluating information may be useful: Categories: CLAIM: A Swedish study shows that Pfizer's COVID-19 vaccine changes recipients' DNA. As with the Ricke paper, this report presents a theory but not evidence of something happening. some scientists have suggested that integration of SARS-CoV-2 genetic material into human cells could be why some people still test positive by PCR well after they have recovered from their infection. N. Engl. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. The patient And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. The results have in many cases been misinterpreted, the Q&A also stated. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. Saw that there was No reason to change the decision to receive a vaccine based on the...., full of protein and chocolate coronavirus to trigger an immune response Your Thoughts on that line Huh7 leading... Made with thick sausages and long green and red peppers in a rich sauce... In place.. Getty badbunny logical fallacies ( hasty generalization and appeal to ignorance ) version the. Other points About this paper are worth noting: Misclassification of study and fallacies. 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